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Positelle™ helps support a positive mood, alleviate occasional stress and encourage restful sleep.*

5 reviews


When experiencing bouts of negative mood, finding your way out can be difficult. Low mood often comes with feelings of occasional stress, and when you’re stressed out, it’s hard to get the sleep you need. Lack of sleep can cause your mood to deteriorate further, sending you into a vicious downward spiral. Unlike other mood stabilizers that address just one of these three issues, Positelle™ addresses all three in one safe and powerful formula.* With Positelle™, you can begin feeling like your best self again.*

Together, the ingredients in Positelle™ help:

  • Safely uplift mood.* Venetron®, rhodiola root extract, lavender oil, vitamin D3, and Quatrefolic® folate have all been clinically shown to support a positive mood.*

  • Promote feelings of calmness.* Venetron®, rhodiola root extract, and lavender oil have been clinically shown to help alleviate occasional stress, thereby inducing feelings of calm and relaxation.*

  • Encourage restful sleep.* Venetron® has been clinically shown to improve sleep quality, while lavender oil also helps people sleep longer and more restoratively.*
100% of our Ingredients are Backed by Human Clinical Studies. Click on any ingredient below to view the research abstracts.

Suggested Use: 3 capsules daily: 1 with each meal for best results.

Supplements Facts

Serving Size: 3 capsules

Servings Per Container: 30

Amount Per Serving

% Daily Value

600 IU  150%

Folate (as Quatrefolic®)

400 IU 100%

[6S]-5-methyltetrahydrofolic acid equivalent to 1.6 mg

of [6S]-5-methyltetrahydrofolic acid, glucosamine salt

125 mg †


276 mg †

(Standardized to 3% salidrosides [8.28 mg])

Lavender Oil (flower)

80 mg †

† Daily value not established.

Other ingredients: maltodextrin, vegetable cellulose, silica, l-leucine, sucrose, modified starch.





Folate is a B-vitamin that is naturally present in many foods. The recommended daily intake of folate is 400 micrograms, which is important to meet, as scientific research links a shortage of folate with low mood. However, much of the population is unable to absorb the folic acid from food or supplements. Quatrefolic® solves this absorption issue, as it is a proprietary form of reduced and methylated folate. Quatrefolic passes the gastric barrier and is absorbed mainly in the small intestine to enable a higher folate uptake.

Vitamin D3

Vitamin D is often called the “sunshine vitamin” because the body can synthesize it when sunlight exposure is adequate. However, researchers have discovered that vitamin D insufficiency is surprisingly common, affecting as much as 70 percent of the population. Vitamin D is a great multi-tasker: it strengthens bone by aiding calcium absorption, modulates immune function, protects prostate cells, and boosts brain chemicals needed for positive mood.* Vitamin D3 is better absorbed than vitamin D2.*


Venetron® is a patented extract of the herb Apocynum venetum that has been shown in several double-blind human clinical trials to support a positive mood.* It has many of the same active constituents as St. John’s wort, but it is safe to use with common pharmaceuticals.* In addition to lifting mood, Venetron® has been shown to calm simple nervous tension and to improve sleep quality.*


Rhodiola rosea is a root extract from an Arctic herb. Rhodiola is an adaptogen, meaning it helps the body adapt to various stressors.* It supports a positive mood by increasing levels of serotonin and other neurotransmitters helping them cross the blood-brain barrier, and decreasing MAO (monoamine oxidase), which degrades these chemicals.*

Lavender Oil

Lavender Oil is an essential oil obtained by distillation from the flower spikes of certain species of lavender. It has been shown to help alleviate feelings of everyday tension, possibly by increasing the expression of the calm neurotransmitter GABA.* Studies have also shown that it could help people sleep longer and more restoratively.*


Q: Will this supplement cause drowsiness?

A: Postielle does not cause drowsiness, but it does promote feeling of calm, therefore making you feel more relaxed which will help make it easier to have a restful sleep if needed.*

Q: What is the difference between all your mood products?

A: Our three mood support products are Positelle, Sernelle and Serotonin. All of which offer separate benefits:

  • Positelle - Supports a positive mood, calmness, and a restful sleep.*
  • Serenelle - Reduces stress without the drowsiness by balancing the hormones in your body and also improving metal alertness.*
  • PureBalance Serotonin - May increase levels of serotonin within body. Increased levels of serotonin decrease food cravings and appetite, increase overall mood, and decrease occasional stress.*
Customer Reviews
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Filter Reviews:
Pamela H.
United States United States

Love this product!!!

Love this product!!!

Lauryn C.
United States

A new lifelong customer

I use this to help battle my negative moods! It works like a gem and helps me sleep

A Quality of Life Labs Customer
jann o.
United States

Love these

The best. Very calming


Good uplifting product

Good uplifting product, I bought this locally and because of the positive results l felt, I ordered it for a friend out of state to give a try.

Jerry C.

Good product for the price

Works extremely well. I have enjoyed a deeper sleep and have found it easier to fall asleep.

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Disclaimer: Reviews and ratings are provided for informational purposes only and solely reflect the views and opinions expressed by the individual contributors and not those of Quality of Life. Your results and experience with the product may differ.