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AHCC® is an effective, well-absorbed and proprietary mushroom extract backed by over 30 human clinical studies.

53 reviews

The immune system is complex.

Like, really complex...

If it’s under active your defenses are low, if it’s overactive then it can attack the body by mistake. Talk about sensitive!

Let’s make it a little less complicated shall we?

Introducing Quality of Life’s AHCC supplements. All-natural, safe, immunomodulating supplements that work to improve overall immune system performance, increase the activity of certain white blood cells and fill your body with energy!


A cultured extract of hybridized medicinal mushroom mycelia (roots), AHCC® is one of the world's most researched specialty immune supplements, supported by over 30 human clinical studies.

AHCC has been shown to:

  • Maintain optimal NK cell activity.*
  • Increase number and activity of dendritic cells.*
  • Promote T-cell and macrophage activity.*
  • Enhance cytokine production.*

Providing 67% greater potency, each 300 mg softgel of AHCC-Rx is equivalent to one 500 mg capsule of AHCC. The new, smaller softgels are easy to swallow and enable a divided AM/PM dose.

100% of our Ingredients are Backed by Human Clinical Studies. Click on any ingredient below to view the research abstracts.

Suggested Use: 2 softgels (up to 3 times) daily before meal.

Supplements Facts

Serving Size: 2 softgels 

Serving Per Container: 30

Amount Per Serving

% Daily Value

600 mg

Mycelia extract of hybridized basidiomycetes (Lentinula edodes) mushrooms (with acetylated alpha-glucans), dextrin (tapioca), alpha-cyclodextrin (vegetable)

Daily value not established.

Other ingredients: soybean oil, soy lecithin, beeswax (yellow), fumed silica, food starch, carrageenan, glycerin, sorbitol, purified water, caramel powder.





AHCC® is a patented, low-molecular weight medicinal mushroom extract developed from the mycelia (or underground portion) of a particular subspecies of Lentinula edodes. Supported by more than 30 human clinical studies, AHCC prompts an early activation of the immune system.* It works by enhancing the production of cytokines (immune-signaling molecules) and increasing the activity of certain white blood cells, including NK cells, DC cells, T-cells, and macrophages.*


Q: What is the difference between the AHCC used in the AHCC Rx formula and the AHCC used in the Kinoko Gold and Platinum products?

A: The AHCC used in AHCC Rx (called AHCC FD) has a higher potency than the regular AHCC used in our other AHCC products. Each 300 mg softgel of AHCC Rx is equivalent to one 500 mg capsule of regular AHCC.

Q: If I am allergic to mushrooms can I take AHCC?

A: Allergies to mushrooms are most often associated with exposure to mushroom spores. These spores originate in the top of the mushroom, called the fruiting body. However, AHCC is derived from the mycelia, or the root of the mushroom, which does not contain spores. In addition, as part of the manufacturing process, the raw material is subjected to a fermentation process that breaks down the high molecular weight molecules that are very tough to digest, into low molecular weight compounds. This process further lowers any allergenic potential. Many people who believe they are allergic to mushrooms take AHCC successfully. However, if you are concerned, please check with a healthcare professional that specializes in natural products or begin taking AHCC very slowly. This can be done by starting with a quarter of a capsule on the tip of your tongue and if you don't experience itching in your mouth or other signs of allergy, work your way up to 2 to 6 capsules per day over a period of several days.

Q: Does AHCC lose its effectiveness over time? 

A: No AHCC does not lose its effectiveness overtime. As shown in an AHCC placebo controlled scientific trial, patients who used AHCC regularly over a ten year period had consistent and significant improvement as compared to the placebo group, therefore showing no signs of the ingredient losing effectiveness.*

Q: Can AHCC be taken with other medications?

A: Two studies conducted at the highly prestigious MD Anderson Cancer Center and published in the Journal of Integrative Oncology explored AHCC’s interaction with other medications. These studies determined that AHCC is metabolized via a pathway called “P450 2D6,” meaning that AHCC has the potential to increase or decrease the absorption of a drug that uses the same pathway. There are few drugs that use the P450 2D6 pathway. In case of cancer treatment, the only mainline chemotherapies that use this pathway are Doxorubicin and Tamoxifen while other chemotherapeutic drugs use different pathways from the one used by AHCC.

Therefore if you are taking another medication and are concerned about possible interactions, we recommend you ask a medical professional if the drug you are taking is metabolized through the cytochrome P450 2D6 class of enzymes. Most likely the answer will be “no” which means that AHCC is highly unlikely to interact with the drug you are taking.


For more information about AHCC, please visit www.ahccresearch.com

Customer Reviews
4.5 Based on 53 Reviews
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Filter Reviews:
Michael A.
United States United States


Great small size easy to take

United States United States

Great Immune Booster

These vitamins are amazing. I am very pleased with how they work. I can feel a difference in my energy level and alertness.

United States United States

good product

I have reviewed other products and this one is a high quality product. When I received my last shipment, two glass bottles of AHCC mushroom extract were broken and customer service was sending replacement bottles.

Theresa K.
United States United States

Beginner product

Referred by my pathologist

greg s.
United States United States

Great product

I’ve been using this product for about it 6 months I think it’s giving great results. Thxs

Julie K.
United States

great product.

I can feel the difference great product.

Leo M.
United States


Awesome product

Nancy F.
United States

Quality Product

I am very impressed not only with this company but also with their high quality products. I don't worry about what I'm putting in my body when I take Quality of Life Products because I know from experience that this company only sells top of the line, high quality products. Thank you

Nancy F.
United States

High Quality Product

I take this product daily as a preventative and am happy to say I find Quality of Life products very high quality with no artificial ingredients. Love you products. Thank you

leeda e.
United States

Great results

I have been using this AHCC for years now. This product is of great quality & helps me deal with my health issues. I only trust this brand!

Danford V.
United States

So far, so good

My immune system seems to be working fine, but it will take a while longer to judge the effect on my NK cells. I have high hopes! I do love the small capsules -- very easy to take.

Nancy F.
United States

Excellent Product

This is a great product. I take it to protect my immune system from any invaders. I did my research before ordering and found this product to be the one that I felt was high quality with ingredients that my body would benefit from that I can trust. .

Marc M.
United States

Immunity super charge

I spent a lot of time researching immune supporting supplements and AHCC is one of the forerunners, and Quality of Life has proved to be one of the best suppliers of AHCC.

Holly T.
United States


So far so good!

Danford V.
United States

Easy to Swallow

These pills are wonderfully small and easy to swallow. Also, the QofL promotional e-mails are a cut above average. They are often interesting and useful.

Norma S.
United States

I love this product

I love this product so much I have it auto delivered every month .. I feel great

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Disclaimer: Reviews and ratings are provided for informational purposes only and solely reflect the views and opinions expressed by the individual contributors and not those of Quality of Life. Your results and experience with the product may differ.