Serenelle® helps increase your energy and focus by helping the body: reduce occasional stress, produce calming brain waves and improve mood.

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Most anti-stress products work by sedating the central nervous system, causing drowsiness and impairing mental function. Serenelle® helps you de-stress while increasing your energy and focus.*

  • Reduces occasional stress.*  A human study found that Sensoril® ashwagandha extract significantly reduced symptoms of occasional stress — including anxiety, heart palpitations, irritability, and sleeplessness.*
  • Produces calming brain waves.* L-theanine and natural PharmaGABA™ have been clinically shown to increase the production of alpha brain waves — indicating a relaxed state of alertness.* Synthetic GABA does not have the same effect.
  • Improves mood and mental alertness.* Relesse™ lemon balm extract has been clinically shown to improve stress-induced negative mood and increase mental alertness.* Relesse is guaranteed to contain the specific constituents responsible for lemon balm's cognitive effects.*
  • Balances hormones.* Sensoril has been clinically shown to reduce the stress hormone cortisol, while boosting the energizing hormone DHEA.*
100% of our Ingredients are Backed by Human Clinical Studies. Click on any ingredient below to view the research abstracts.

Suggested Use: 2 vegicaps daily with a meal.

Supplements Facts

Serving Size: 2 vegicaps

Servings Per Container: 30

Amount Per Serving

% Daily Value

Lemon balm leaf extract (Melissa officinalis)

300 mg †

as Relesse™ [standardized to 6% rosmarinic acid (18 mg)]

Sensoril® ashwagandha extract

250 mg †

(Withaniasomnifera) roots and leaves [minimum

8% withanolide glycoside conjugates (20 mg) and

32% oligosaccharides (80 mg)]


200 mg †


125 mg †

(100 mg gamma aminobutyric acid)

† Daily value not established.

Other ingredients: vegetable cellulose, tapioca starch, leucine, silica.

Sensoril® is a registered trademark of Natreon Inc. and is protected under U.S.

Patent #6,713,092. PharmaGABA® is a registered trademark of Pharma Foods International Co. Ltd.





Relesseis a patented lemon balm extract. A double-blind, placebo-controlled human clinical trial found lemon balm effective for improving stress-induced negative mood.* It works by decreasing levels of the stress hormone cortisol and increasing levels of the calming neurotransmitter GABA.*

Sensoril® Ashwagandha extract

Ashwagandha, also known as Indian ginseng or winter cherry, is a flowering shrub native to India and Nepal whose root is used in Ayurvedic medicine. Sensoril® is a proprietary extract of ashwagandha. Double-blind, placebo-controlled human clinical research has shown Sensoril reduces symptoms of occasional stress, such as anxiety and fatigue, by reducing levels of the stress hormone cortisol and increasing levels of the energizing hormone DHEA.*


L-theanine is an amino acid found in tea leaves, particularly green tea. It has been clinically shown to prevent over-stimulation and produce a state of relaxed alertness by producing calming alpha brain waves.* L-theanine works by raising levels of several inhibitory neurotransmitters, including serotonin and GABA, and by preventing L-glutamic acid, an excitatory neurotransmitter, from binding to receptors.*

GABA (gamma aminobutyric acid) (PharmaGABA™)

GABA is an inhibitory neurotransmitter, meaning it has a calming effect on the brain.* But rather than acting as a sedative, GABA has been clinically shown to induce a state of relaxed alertness by increasing the production of lower-frequency alpha brain waves and decreasing the production of nerve-jangling beta waves.* Natural PharmaGABA is more bioavailable than synthetic GABA, possibly because it is better able to cross the blood-brain barrier.*

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Q: Can you take Serenelle while taking antidepressants?

A: For Serenelle it is unlikely that there would be any problem with SSRI's (Selective serotonin reuptake inhibitors). One study shows an indirect pathway for Ashwaganda (Sensoril) increasing serotonin via a cholineacetyltransferase pathway in the hippocampus of the brain. However, we do recommend consulting with a healthcare professional if you have any concerns with other medications you are taking.

Q: What is the difference between synthetic GABA and PharmaGABA?

A: The differences are vast. PharmaGABA is produced naturally with proven safety and efficacy. Synthetic GABA is produced from various toxic chemicals including succinimide, piperylurethan and fuming nitric acid, N-(β-bromoethyl) phthalimide and sodiomalonic ester, and γ-chlorobutyronitrile and potassium phthalimide. These compounds are regarded as noxious substances and thus prohibited to use in foods in many countries. The PharmaGABA used in our Serenelle formula is approved for food use in many countries and is both safe and effective.

Q: What is the difference between all your mood products?

A: Our three mood support products are Positelle, Sernelle and Serotonin. All of which offer separate benefits:

  • Positelle - Supports a positive mood, calmness, and a restful sleep.*
  • Serenelle - Reduces stress without the drowsiness by balancing the hormones in your body and also improving metal alertness.*
  • PureBalance Serotonin - May increase levels of serotonin within body. Increased levels of serotonin decrease food cravings and appetite, increase overall mood, and decrease occasional stress.*

Customer Reviews

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Five Stars

This one works.


Very pleased

I'm an empath, so I tend to absorb other people's energy. I can usually balance this, but I've had some extraordinary stress within a relationship (he's having trouble with his children) and that's brought about sleeplessness because my brain just won't turn off. It began to affect me physically including unbearable itching and scratching, and my hair falling out. It finally got so bad, I went to a regular M.D. who couldn't find anything clinically wrong, so he put me on a standard allergy protocol of steroids and anxiety meds. Not wanting to continue these meds for a prolonged period, my local vitamin store recommended Serenelle as a replacement and it was a small miracle. It really helped the physical side of things which allowed me to work on meditation and other energy work at the same time. Very pleased, and I continue to use this supplement on occasion!

Joan A.

Four Stars

Works great. noticeable when I forget to take .

Nika H

Five Stars

It is helping!


Reliably Helpful

The Serenelle product has been very beneficial for me: there's been a fair improvement in my concentration at work, mainly due to a reduced of feelings of anxiety (which it does help); my overall mood is generally better for it, and initially I fell asleep much better with it (taken twice per day, with food.) (Other sleep aids aren't reliably helpful for me--I'm a trickier case.) Even when I didn't sleep enough, it's much easier for me to get out of bed on those mornings. Taking capsules three times a day seems to have regained my ability to fall asleep soon enough more reliably.