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Serenelle® helps increase your energy and focus by helping the body: reduce occasional stress, produce calming brain waves and improve mood.

30 reviews


Most anti-stress products work by sedating the central nervous system, causing drowsiness and impairing mental function. Serenelle® helps you de-stress while increasing your energy and focus.*

  • Reduces occasional stress.*  A human study found that Sensoril® ashwagandha extract significantly reduced symptoms of occasional stress — including anxiety, heart palpitations, irritability, and sleeplessness.*
  • Produces calming brain waves.* L-theanine and natural PharmaGABA™ have been clinically shown to increase the production of alpha brain waves — indicating a relaxed state of alertness.* Synthetic GABA does not have the same effect.
  • Improves mood and mental alertness.* Relesse™ lemon balm extract has been clinically shown to improve stress-induced negative mood and increase mental alertness.* Relesse is guaranteed to contain the specific constituents responsible for lemon balm's cognitive effects.*
  • Balances hormones.* Sensoril has been clinically shown to reduce the stress hormone cortisol, while boosting the energizing hormone DHEA.*
100% of our Ingredients are Backed by Human Clinical Studies. Click on any ingredient below to view the research abstracts.

Suggested Use: 2 vegicaps daily with a meal.

Supplements Facts

Serving Size: 2 vegicaps

Servings Per Container: 30

Amount Per Serving

% Daily Value

300 mg †

as Relesse™ [standardized to 6% rosmarinic acid (18 mg)]

250 mg †

(Withaniasomnifera) roots and leaves [minimum

8% withanolide glycoside conjugates (20 mg) and

32% oligosaccharides (80 mg)]

200 mg †

125 mg †

(100 mg gamma aminobutyric acid)

† Daily value not established.

Other ingredients: vegetable cellulose, maltodextrin, leucine, silica.

Sensoril® is a registered trademark of Natreon Inc. and is protected under U.S.

Patent #6,713,092. PharmaGABA® is a registered trademark of Pharma Foods International Co. Ltd.





Relesseis a patented lemon balm extract. A double-blind, placebo-controlled human clinical trial found lemon balm effective for improving stress-induced negative mood.* It works by decreasing levels of the stress hormone cortisol and increasing levels of the calming neurotransmitter GABA.*

Sensoril® Ashwagandha extract

Ashwagandha, also known as Indian ginseng or winter cherry, is a flowering shrub native to India and Nepal whose root is used in Ayurvedic medicine. Sensoril® is a proprietary extract of ashwagandha. Double-blind, placebo-controlled human clinical research has shown Sensoril reduces symptoms of occasional stress, such as anxiety and fatigue, by reducing levels of the stress hormone cortisol and increasing levels of the energizing hormone DHEA.*


L-theanine is an amino acid found in tea leaves, particularly green tea. It has been clinically shown to prevent over-stimulation and produce a state of relaxed alertness by producing calming alpha brain waves.* L-theanine works by raising levels of several inhibitory neurotransmitters, including serotonin and GABA, and by preventing L-glutamic acid, an excitatory neurotransmitter, from binding to receptors.*

GABA (gamma aminobutyric acid) (PharmaGABA™)

GABA is an inhibitory neurotransmitter, meaning it has a calming effect on the brain.* But rather than acting as a sedative, GABA has been clinically shown to induce a state of relaxed alertness by increasing the production of lower-frequency alpha brain waves and decreasing the production of nerve-jangling beta waves.* Natural PharmaGABA is more bioavailable than synthetic GABA, possibly because it is better able to cross the blood-brain barrier.*


Q: Can you take Serenelle while taking antidepressants?

A: For Serenelle it is unlikely that there would be any problem with SSRI's (Selective serotonin reuptake inhibitors). One study shows an indirect pathway for Ashwaganda (Sensoril) increasing serotonin via a cholineacetyltransferase pathway in the hippocampus of the brain. However, we do recommend consulting with a healthcare professional if you have any concerns with other medications you are taking.

Q: What is the difference between synthetic GABA and PharmaGABA?

A: The differences are vast. PharmaGABA is produced naturally with proven safety and efficacy. Synthetic GABA is produced from various toxic chemicals including succinimide, piperylurethan and fuming nitric acid, N-(β-bromoethyl) phthalimide and sodiomalonic ester, and γ-chlorobutyronitrile and potassium phthalimide. These compounds are regarded as noxious substances and thus prohibited to use in foods in many countries. The PharmaGABA used in our Serenelle formula is approved for food use in many countries and is both safe and effective.

Q: What is the difference between all your mood products?

A: Our three mood support products are Positelle, Sernelle and Serotonin. All of which offer separate benefits:

  • Positelle - Supports a positive mood, calmness, and a restful sleep.*
  • Serenelle - Reduces stress without the drowsiness by balancing the hormones in your body and also improving metal alertness.*
  • PureBalance Serotonin - May increase levels of serotonin within body. Increased levels of serotonin decrease food cravings and appetite, increase overall mood, and decrease occasional stress.*
Customer Reviews
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United States United States

Love the product, but…..

I love Serenelle. It does just what they say it does, but it seems every time I order it, it is out of stock.

United States United States


Good experience, would recommend to others

Michell O.
United States United States

This is awesome

This product is wonderful. I’ll take it the night before and the next day I wake up ready to conquer. I can as well tell when my body needs it.

United States United States

It works!

I have been taking it for a year and I can notice when I skip it. It really makes my daily life peaceful.

United States United States

Works for me!

Taking 2 pills a day and I can relax much better

Bernadette M.
United States United States

Grad school daughter’s csaving grace!

My daughter is in Grad school and extremely stressed out...our local Health Food store recommended Serenelle and we are eternally grateful! It has made a major difference in her life...not only is she less anxious but she actually feels more focused when she takes it! We now order directly from Quality of Life and love the quick shipping and awesome price! Thank you!

Lilit D.
United States


Wonderful product!

Lilit D.
United States


Great product. Finally a product that works for me.

United States

Great product

This is a great mixture that calms.

Clara C.
United States

It works for me.

I could feel that it calms me down

Selina F.
United States

Happy with the results thus far

I purchased Serenelle for my teenage daughter. She's Moody and restless at night and stresses very easily over school, homework etc She's been sleeping much better since starting this supplement (she hasn't wandered into my room at 3 am with "Mooooom I can't sleep" since starting Serenelle) I'll update further when she's on her 2nd month of this supplement.


Five Stars

This one works.

Joan A.

Four Stars

Works great. noticeable when I forget to take .

Nika H.

Five Stars

It is helping!

Sheri W.

After about a week of taking I started to sleep better and now unless I have to go to the ...

I started using this product on a recommendation from my cousin because I was having trouble staying asleep. After about a week of taking I started to sleep better and now unless I have to go to the bathroom I am sleeping through the night. Before taking I would fall asleep with no problem but within a couple of hours I'd be up and getting back to sleep was such a problem. Very happy with this product and would highly recommend it.


Reliably Helpful

The Serenelle product has been very beneficial for me: there's been a fair improvement in my concentration at work, mainly due to a reduced of feelings of anxiety (which it does help); my overall mood is generally better for it, and initially I fell asleep much better with it (taken twice per day, with food.) (Other sleep aids aren't reliably helpful for me--I'm a trickier case.) Even when I didn't sleep enough, it's much easier for me to get out of bed on those mornings. Taking capsules three times a day seems to have regained my ability to fall asleep soon enough more reliably.

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Disclaimer: Reviews and ratings are provided for informational purposes only and solely reflect the views and opinions expressed by the individual contributors and not those of Quality of Life. Your results and experience with the product may differ.