21   |  
Subscription details
How AutoRefill Works:

- Auto-ship allows you replenish Quality of Life supplements without the trouble of ordering again. It's convenient, affordable and easy.

- With our AutoRefill program, you lock in a discount on our natural supplements for as long as you are a customer! We often raise product prices because we use premium ingredients and these costs go up. Lock in a special discount forever at this price.

- We notify you via email before each shipment, so you can pause, skip, modify or even cancel before your next shipments. It's easy and hassle free.


Serenelle® helps increase your energy and focus by helping the body: reduce occasional stress, produce calming brain waves and improve mood.

  • FAQ


Most anti-stress products work by sedating the central nervous system, causing drowsiness and impairing mental function. Serenelle® helps you de-stress while increasing your energy and focus.*

  • Reduces occasional stress.*  A human study found that Sensoril® ashwagandha extract significantly reduced symptoms of occasional stress — including anxiety, heart palpitations, irritability, and sleeplessness.*
  • Produces calming brain waves.* L-theanine and natural PharmaGABA™ have been clinically shown to increase the production of alpha brain waves — indicating a relaxed state of alertness.* Synthetic GABA does not have the same effect.
  • Improves mood and mental alertness.* Relesse™ lemon balm extract has been clinically shown to improve stress-induced negative mood and increase mental alertness.* Relesse is guaranteed to contain the specific constituents responsible for lemon balm's cognitive effects.*
  • Balances hormones.* Sensoril has been clinically shown to reduce the stress hormone cortisol, while boosting the energizing hormone DHEA.*

Supplements Facts





Relesseis a patented lemon balm extract. A double-blind, placebo-controlled human clinical trial found lemon balm effective for improving stress-induced negative mood.* It works by decreasing levels of the stress hormone cortisol and increasing levels of the calming neurotransmitter GABA.*

Sensoril® Ashwagandha extract

Ashwagandha, also known as Indian ginseng or winter cherry, is a flowering shrub native to India and Nepal whose root is used in Ayurvedic medicine. Sensoril® is a proprietary extract of ashwagandha. Double-blind, placebo-controlled human clinical research has shown Sensoril reduces symptoms of occasional stress, such as anxiety and fatigue, by reducing levels of the stress hormone cortisol and increasing levels of the energizing hormone DHEA.*


L-theanine is an amino acid found in tea leaves, particularly green tea. It has been clinically shown to prevent over-stimulation and produce a state of relaxed alertness by producing calming alpha brain waves.* L-theanine works by raising levels of several inhibitory neurotransmitters, including serotonin and GABA, and by preventing L-glutamic acid, an excitatory neurotransmitter, from binding to receptors.*

GABA (gamma aminobutyric acid) (PharmaGABA™)

GABA is an inhibitory neurotransmitter, meaning it has a calming effect on the brain.* But rather than acting as a sedative, GABA has been clinically shown to induce a state of relaxed alertness by increasing the production of lower-frequency alpha brain waves and decreasing the production of nerve-jangling beta waves.* Natural PharmaGABA is more bioavailable than synthetic GABA, possibly because it is better able to cross the blood-brain barrier.*

Related Items


Q: Can you take Serenelle while taking antidepressants?

A: For Serenelle it is unlikely that there would be any problem with SSRI's (Selective serotonin reuptake inhibitors). One study shows an indirect pathway for Ashwaganda (Sensoril) increasing serotonin via a cholineacetyltransferase pathway in the hippocampus of the brain. However, we do recommend consulting with a healthcare professional if you have any concerns with other medications you are taking.

Q: What is the difference between synthetic GABA and PharmaGABA?

A: The differences are vast. PharmaGABA is produced naturally with proven safety and efficacy. Synthetic GABA is produced from various toxic chemicals including succinimide, piperylurethan and fuming nitric acid, N-(β-bromoethyl) phthalimide and sodiomalonic ester, and γ-chlorobutyronitrile and potassium phthalimide. These compounds are regarded as noxious substances and thus prohibited to use in foods in many countries. The PharmaGABA used in our Serenelle formula is approved for food use in many countries and is both safe and effective.

Q: What is the difference between all your mood products?

A: Our three mood support products are Positelle, Sernelle and Serotonin. All of which offer separate benefits:

  • Positelle - Supports a positive mood, calmness, and a restful sleep.*
  • Serenelle - Reduces stress without the drowsiness by balancing the hormones in your body and also improving metal alertness.*
  • PureBalance Serotonin - May increase levels of serotonin within body. Increased levels of serotonin decrease food cravings and appetite, increase overall mood, and decrease occasional stress.*

Customer Reviews

Based on 21 reviews
5 Star
4 Star
3 Star
2 Star
1 Star
Write a Review Ask a Question
  • Reviews (21)
  • Questions (0)

Thank you for submitting a review!

Your input is very much appreciated. Share it with your friends so they can enjoy it too!
Zak Addison Beckley

Five Stars

Taking 2 in morning is VERY effective and does the job it was intended for.


Five Stars

This one works.


Very pleased

I'm an empath, so I tend to absorb other people's energy. I can usually balance this, but I've had some extraordinary stress within a relationship (he's having trouble with his children) and that's brought about sleeplessness because my brain just won't turn off. It began to affect me physically including unbearable itching and scratching, and my hair falling out. It finally got so bad, I went to a regular M.D. who couldn't find anything clinically wrong, so he put me on a standard allergy protocol of steroids and anxiety meds. Not wanting to continue these meds for a prolonged period, my local vitamin store recommended Serenelle as a replacement and it was a small miracle. It really helped the physical side of things which allowed me to work on meditation and other energy work at the same time. Very pleased, and I continue to use this supplement on occasion!

Joan Antognoni

Four Stars

Works great. noticeable when I forget to take .

Nika H

Five Stars

It is helping!