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Serotonin (PureBalance™)

PureBalance™ Serotonin provides the raw material your body needs to make serotonin. This key neurotransmitter is important for strong immunity — not to mention relaxation, a positive mood, and restful sleep.

114 reviews


You know serotonin is important for mood, but did you know it also supports immune function? If immune cells are cars, serotonin is a traffic copy; it directs them to travel to troubled areas in the body. Serotonin also modulates the release of cytokines, which help coordinate a response to immune threats. In that way, serotonin directly impacts immune function.

But serotonin also indirectly supports immunity, because it helps you manage stress, maintain a positive mood, and enjoy restful sleep — all key for a strong immune system.

PureBalance™ Serotonin includes 5-HTP, the raw material your body uses to make serotonin.* The actions of serotonin are reinforced with ingredients for:

  • Immunity: Vitamin D supports overall immunity and helps promotes upper respiratory tract health.*
  • Stress management: Rhodiola rosea helps the body adapt to stress, while L-theanine calms the brain.* Relora® may also reduce stress and stress-related eating.*
  • Mood support: Insufficient vitamin D may negatively affect mood, while Rhodiola rosea has been used for centuries to promote a positive outlook.*
  • Sleep support: L-theanine encourages the transition from the beta brain waves of mental arousal to the alpha brain waves of relaxation.*
100% of our Ingredients are Backed by Human Clinical Studies. Click on any ingredient below to view the research abstracts.

Suggested Use: 1 capsule three times daily before meals.

Supplements Facts

Serving Size: 1 capsules

Servings Per Container: 90

Amount Per Serving

% Daily Value

Vitamin D3 (as cholecalciferol)

267 IU 67%

33 mg †

(fromGriffoniasimplicifolia) (seed)

67 mg †

250 mg †

Magnolia standardized bark extract

Phellodendron standardized bark extract

120 mg †

(Standardized for 5% rosavins [6 mg])

*Percent values are based on a 2,000 calorie diet
† Daily value not established.

Other ingredients: vegetable cellulose, leucine, pregelatinized food starch, corn starch, silica, olive oil, tapioca dextrin.




Vitamin D3 (cholecalciferol)

Vitamin D is often called the “sunshine vitamin” because the body can synthesize it when sunlight exposure is adequate. However, researchers have discovered that vitamin D insufficiency is surprisingly common, affecting as much as 70 percent of the population. Vitamin D is a great multi-tasker: it strengthens bone by aiding calcium absorption, modulates immune function, protects prostate cells, and boosts brain chemicals needed for positive mood.* Vitamin D3 is better absorbed than vitamin D2.*

5-HTP(L-5 Hydroxy- tryptophan)

5-HTP is naturally occurring amino acid and the raw material the body uses to make serotonin — a brain chemical necessary for positive mood, healthy sleep, and appetite. Research has shown that when levels of 5-HTP rise, so do levels of serotonin. Several double-blind, placebo-controlled human trials have found 5-HTP can help support a positive mood, reduce appetite, and enhance weight loss.*

Rhodiola root extract

Rhodiola rosea (also called golden root) is a plant that grows in cold regions across the world. Rhodiola is an adaptogen, meaning it helps the body adapt to various stressors. *


Relora is a proprietary blend of standardized extracts of magnolia and phellodendron bark. It contains the calming compounds berberine and honokiol and may alleviate symptoms of occasional stress and stress-related overeating by reducing levels of the stress hormone coritsol.* Cortisol causes weight gain by increasing both appetite and fat formation, so a reduction in this hormone helps support weight loss efforts in two ways.*


L-theanine is an amino acid found in tea leaves, particularly green tea. It has been clinically shown to prevent over-stimulation and produce a state of relaxed alertness by producing calming alpha brain waves.* L-theanine works by raising levels of several inhibitory neurotransmitters, including serotonin and GABA, and by preventing L-glutamic acid, an excitatory neurotransmitter, from binding to receptors.*


Q: Can you take Serotonin while taking antidepressants?

A:  According to a study conducted by the University of Maryland, there are dangers in consuming both 5HTP and SSRI's (Selective serotonin reuptake inhibitors) together. This can cause a dangerous serotonin syndrome that can lead to a coma. In general, you should be aware of your intake of medications that affect your serotonin levels if you are considering taking Serotonin. Please consult with your doctor if you have any concerns.

Q: What is the difference between all your mood products?

A: Our three mood support products are Positelle, Sernelle and Serotonin. All of which offer separate benefits:

Positelle - Supports a positive mood, calmness, and a restful sleep.*

Serenelle - Reduces stress without the drowsiness by balancing the hormones in your body and also improving metal alertness.*

PureBalance Serotonin - May increase levels of serotonin within body. Increased levels of serotonin decrease food cravings and appetite, increase overall mood, and decrease occasional stress.*

Customer Reviews
4.6 Based on 114 Reviews
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Filter Reviews:
Joel T.
United States United States

Working great

It’s working nicely. My emotions have evened out and I’m not as agitated

United States United States

Good product!

I have been using this product for years now. Highly recommended!

United States United States


Great stuff! I am getting ready to order some more!

United States United States

Pure Balance Serotonin

been taking it for about 3 months now. I am sleeping better and have noticed that i have more energy,

Diana B.
United States United States

Just what I needed.

My son recommended this product after purchasing it for his wife and watching her anxiety reduce tremendously. I was going through a intense time of trial, and this product, as opposed to others similar to it, helped me a great deal. I felt balanced, calm and many times even cheerful all throughout.

United States United States


I rely on Quality of Life serotonin to help keep my stress level on an even keel and to help with stress eating !

Claritha H.
United States United States

Feel Great

I'm finishing up my 2nd bottle and I love how much better I am feeling now.

Pat C.
United States United States


After taking them for about a week I noticed the difference in my whole mindset. I was sleeping better and less anxious.

United States United States

Good Nights Sleep

Help in Dreamland. Able to use bathroom and return easily to sleep!

Mary B.
United States United States

So far so good!

I've been using this for about 6 months now and I have noticed an over all balance of my mood! I have been consciously trying to move my body and enjoy outside activities. Sunshine & exercise helps boost the serotonin even more. I'm more stable and happy and not quick to get flustered. I have added Serenelle about 3 weeks ago and they pair perfectly!

Claritha H.
United States United States

Feel Great

Just started taking them but I feel great. My anxiety has lowered and I'm looking forward to this new journey.

William M.
United States


Pure Balance Serotonin is the best. Wish I had had it a long time ago.

Susan L.
United States

Review of serotonin

I felt at a calmness of myself. My hormones are not everywhere. An overall feeling of calmness. Haven’t felt the effects of sleeping better but overall just not reacting quickly and getting upset about certain thing, I wait, with a pause of calmness.

Mariana A.
United States

Was very helpful

Helped with my moods and stress. Will be a recurring customer

Susan L.
United States

Product: Serotonin( Pure Balance)

So far, so good. I’ve diffently noticed an overwhelming sense of calmness. Hormones are at an even level of relief . At 2 weeks, 2x daily, I’ve noticed a change

Lised J.
United States


Really do feel a difference in energy and hunger

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Disclaimer: Reviews and ratings are provided for informational purposes only and solely reflect the views and opinions expressed by the individual contributors and not those of Quality of Life. Your results and experience with the product may differ.